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STEMCELL Technologies Inc stemspan serum-free expansion medium 09650
Stemspan Serum Free Expansion Medium 09650, supplied by STEMCELL Technologies Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/serum-free+stemspan+medium/stemspan+serum+free+expansion+medium/pm40670787-630-5-12
Average 90 stars, based on 1 article reviews
stemspan serum-free expansion medium 09650 - by Bioz Stars, 2026-09
90/100 stars

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Transduction:

Article Title: Method for improving retroviral transduction and gene editing in hematopoietic stem cells using cyclosporine h (CsH)
Article Snippet: Monocyte-derived macrophages (MDM) were differentiated from isolated CD14+ monocytes in DMEM supplemented with 10% FBS, penicillin (100 IU/ml), streptomycin (100 μg/ml), 2% glutamine and 5% human serum AB (Lonza) for seven days. .. All cells were maintained in a 5% CO2 humidified atmosphere at 37° C. Transduction Human CB-derived haematopoietic stem/progenitor cells (HSPCs) were cultured in serum-free StemSpan medium (StemCell Technologies) supplemented with penicillin (100 IU/ml), streptomycin (100 μg/ml), 100 ng/ml recombinant human stem cell factor (rhSCF), 20 ng/ml recombinant human thrombopoietin (rhTPO), 100 ng/ml recombinant human Flt3 ligand (rhFlt3), and 20 ng/ml recombinant human IL6 (rhIL6) (all from Peprotech) 16 to 24 hours prior to transduction. ..

Article Title: Removal of innate immune barriers allows efficient transduction of quiescent human hematopoietic stem cells.
Article Snippet: Human CD34+ cells were either freshly purified from umbilical CB collected upon informed consent from healthy volunteers according to the Institutional Ethical Committee approved protocol (TIGET01/09), or purchased frozen from Lonza as for G-CSF mPB CD34+ cells. .. Human CB-derived HSPC were cultured in serum-free StemSpan medium (STEMCELL Technologies) supplemented with penicillin (100 IU/mL), streptomycin (100 mg/mL), 100 ng/mL recombinant human stem cell factor (rhSCF), 20 ng/mL recombinant human thrombopoietin (rhTPO), 100 ng/mL recombinant human Flt3 ligand (rhFlt3), and 20 ng/mL recombinant human IL6 (all from Peprotech) for 16–24 h prior to transduction. mPBderived HSPC were cultured in CellGro medium (CellGenix) supplemented with penicillin (100 IU/mL), streptomycin (100 mg/mL), 300 ng/mL rhSCF, 100 ng/mL rhTPO, 300 ng/mL rhFlt3, and 50 ng/mL recombinant human IL3 for 16–24 h prior to transduction.8,38 Unstimulated HSPC were kept in the same media in the absence of cytokines during transduction for 16–20 h and then supplemented with the above described human cytokines and 10 mM of the reverse transcriptase inhibitor 3TC (Sigma) to avoid subsequent transduction due to cytokines stimulation. ..

Cell Culture:

Article Title: Method for improving retroviral transduction and gene editing in hematopoietic stem cells using cyclosporine h (CsH)
Article Snippet: Monocyte-derived macrophages (MDM) were differentiated from isolated CD14+ monocytes in DMEM supplemented with 10% FBS, penicillin (100 IU/ml), streptomycin (100 μg/ml), 2% glutamine and 5% human serum AB (Lonza) for seven days. .. All cells were maintained in a 5% CO2 humidified atmosphere at 37° C. Transduction Human CB-derived haematopoietic stem/progenitor cells (HSPCs) were cultured in serum-free StemSpan medium (StemCell Technologies) supplemented with penicillin (100 IU/ml), streptomycin (100 μg/ml), 100 ng/ml recombinant human stem cell factor (rhSCF), 20 ng/ml recombinant human thrombopoietin (rhTPO), 100 ng/ml recombinant human Flt3 ligand (rhFlt3), and 20 ng/ml recombinant human IL6 (rhIL6) (all from Peprotech) 16 to 24 hours prior to transduction. ..

Article Title: Removal of innate immune barriers allows efficient transduction of quiescent human hematopoietic stem cells.
Article Snippet: Human CD34+ cells were either freshly purified from umbilical CB collected upon informed consent from healthy volunteers according to the Institutional Ethical Committee approved protocol (TIGET01/09), or purchased frozen from Lonza as for G-CSF mPB CD34+ cells. .. Human CB-derived HSPC were cultured in serum-free StemSpan medium (STEMCELL Technologies) supplemented with penicillin (100 IU/mL), streptomycin (100 mg/mL), 100 ng/mL recombinant human stem cell factor (rhSCF), 20 ng/mL recombinant human thrombopoietin (rhTPO), 100 ng/mL recombinant human Flt3 ligand (rhFlt3), and 20 ng/mL recombinant human IL6 (all from Peprotech) for 16–24 h prior to transduction. mPBderived HSPC were cultured in CellGro medium (CellGenix) supplemented with penicillin (100 IU/mL), streptomycin (100 mg/mL), 300 ng/mL rhSCF, 100 ng/mL rhTPO, 300 ng/mL rhFlt3, and 50 ng/mL recombinant human IL3 for 16–24 h prior to transduction.8,38 Unstimulated HSPC were kept in the same media in the absence of cytokines during transduction for 16–20 h and then supplemented with the above described human cytokines and 10 mM of the reverse transcriptase inhibitor 3TC (Sigma) to avoid subsequent transduction due to cytokines stimulation. ..

Article Title: Non-genotoxic conditioning facilitates hematopoietic stem cell gene therapy for hemophilia A using bioengineered factor VIII
Article Snippet: Labeled cells were then passed through an LS column loaded on a MidiMACS Separator (Miltenyi). .. Sca-1 + cells were harvested and cultured in serum-free StemSpan medium (Stem Cell Technologies, Vancouver, BC, Canada) for 3 days in the presence of mouse SCF (100 ng/mL), mouse IL-3 (20 ng/mL), human IL-11 (100 ng/mL), and human Flt-3 ligand (100 ng/mL). .. All cytokines were purchased from R&D Systems (Minneapolis, MN, USA).

Article Title: Human Melanoma-Associated Mast Cells Display a Distinct Transcriptional Signature Characterized by an Upregulation of the Complement Component 3 That Correlates With Poor Prognosis
Article Snippet: Briefly, CD117 + progenitor cells were purified from PBMCs by using a positive selection kit (Miltenyi Biotec, Bergisch Gladbach, Germany) following the manufacturer’s instructions. .. Progenitor cells were cultured in Serum-Free StemSpan Medium (STEMCELL Technologies, Canada) supplemented with 100 U/ml penicillin (Invitrogen), 100 μg/ml streptomycin (Invitrogen), human IL-3 (10 ng/ml, PeproTech, USA), human stem cell factor (100 ng/ml, PeproTech, USA), and human IL-6 (50 ng/ml, PeproTech, USA). .. After 4 weeks, cells were progressively transferred to culture medium 2 containing Iscove’s modified Dulbecco medium with GlutaMAX-I, 50 μmol/L β 2 -mercaptoethanol, 0.5% BSA, 1% Insulin-Transferrin-Selenium (Life Technologies, USA), 100 U/ml penicillin, 100 μg/ml streptomycin, human stem cell factor (100 ng/ml), and human IL-6 (50 ng/ml).

Recombinant:

Article Title: Method for improving retroviral transduction and gene editing in hematopoietic stem cells using cyclosporine h (CsH)
Article Snippet: Monocyte-derived macrophages (MDM) were differentiated from isolated CD14+ monocytes in DMEM supplemented with 10% FBS, penicillin (100 IU/ml), streptomycin (100 μg/ml), 2% glutamine and 5% human serum AB (Lonza) for seven days. .. All cells were maintained in a 5% CO2 humidified atmosphere at 37° C. Transduction Human CB-derived haematopoietic stem/progenitor cells (HSPCs) were cultured in serum-free StemSpan medium (StemCell Technologies) supplemented with penicillin (100 IU/ml), streptomycin (100 μg/ml), 100 ng/ml recombinant human stem cell factor (rhSCF), 20 ng/ml recombinant human thrombopoietin (rhTPO), 100 ng/ml recombinant human Flt3 ligand (rhFlt3), and 20 ng/ml recombinant human IL6 (rhIL6) (all from Peprotech) 16 to 24 hours prior to transduction. ..

Article Title: Removal of innate immune barriers allows efficient transduction of quiescent human hematopoietic stem cells.
Article Snippet: Human CD34+ cells were either freshly purified from umbilical CB collected upon informed consent from healthy volunteers according to the Institutional Ethical Committee approved protocol (TIGET01/09), or purchased frozen from Lonza as for G-CSF mPB CD34+ cells. .. Human CB-derived HSPC were cultured in serum-free StemSpan medium (STEMCELL Technologies) supplemented with penicillin (100 IU/mL), streptomycin (100 mg/mL), 100 ng/mL recombinant human stem cell factor (rhSCF), 20 ng/mL recombinant human thrombopoietin (rhTPO), 100 ng/mL recombinant human Flt3 ligand (rhFlt3), and 20 ng/mL recombinant human IL6 (all from Peprotech) for 16–24 h prior to transduction. mPBderived HSPC were cultured in CellGro medium (CellGenix) supplemented with penicillin (100 IU/mL), streptomycin (100 mg/mL), 300 ng/mL rhSCF, 100 ng/mL rhTPO, 300 ng/mL rhFlt3, and 50 ng/mL recombinant human IL3 for 16–24 h prior to transduction.8,38 Unstimulated HSPC were kept in the same media in the absence of cytokines during transduction for 16–20 h and then supplemented with the above described human cytokines and 10 mM of the reverse transcriptase inhibitor 3TC (Sigma) to avoid subsequent transduction due to cytokines stimulation. ..

Concentration Assay:

Article Title:
Article Snippet: G-CSF mPB CD34+ HSPCs were purified with the CliniMACS CD34 Reagent System (Miltenyi Biotec) from Mobilized Leukopak (AllCells) upon approval by the Ospedale San Raffaele Bioethical Committee (TIGET-HPCT) according to manufacturer’s instructions. .. HSPCs were seeded at the concentration of 5x105 cells/ml in serum-free StemSpan medium (StemCell Technologies) supplemented with 100 IU/ml penicillin, 100 μg/ml streptomycin, 2% glutamine, 300 ng/ml hSCF, 300 ng/ml hFlt3-L, 100 ng/ml hTPO and 10 μM PGE2 (at the beginning of the culture). ..

Article Title: Efficient gene editing of human long-term hematopoietic stem cells validated by clonal tracking
Article Snippet: .. CB CD34 + HSPCs were purchased frozen from Lonza upon approval by the Ospedale San Raffaele Bioethical Committee (TIGET-HPCT) and were seeded at the concentration of 5x10 5 cells/ml in serum-free StemSpan medium (StemCell Technologies) supplemented with 100 IU/ml penicillin, 100 μg/ml streptomycin, 2% glutamine, 100 ng/ml hSCF (PeproTech), 100 ng/ml hFlt3-L (PeproTech), 20 ng/ml hTPO (PeproTech), and 20 ng/ml hIL-6 (PeproTech) and 10 μM PGE 2 (at the beginning of the culture; Cayman). .. Culture medium was also supplemented with 1 μM SR1 (Biovision) and 50 nM UM171 (STEMCell Technologies), unless otherwise specified.

Reverse Transcription:

Article Title: Removal of innate immune barriers allows efficient transduction of quiescent human hematopoietic stem cells.
Article Snippet: Human CD34+ cells were either freshly purified from umbilical CB collected upon informed consent from healthy volunteers according to the Institutional Ethical Committee approved protocol (TIGET01/09), or purchased frozen from Lonza as for G-CSF mPB CD34+ cells. .. Human CB-derived HSPC were cultured in serum-free StemSpan medium (STEMCELL Technologies) supplemented with penicillin (100 IU/mL), streptomycin (100 mg/mL), 100 ng/mL recombinant human stem cell factor (rhSCF), 20 ng/mL recombinant human thrombopoietin (rhTPO), 100 ng/mL recombinant human Flt3 ligand (rhFlt3), and 20 ng/mL recombinant human IL6 (all from Peprotech) for 16–24 h prior to transduction. mPBderived HSPC were cultured in CellGro medium (CellGenix) supplemented with penicillin (100 IU/mL), streptomycin (100 mg/mL), 300 ng/mL rhSCF, 100 ng/mL rhTPO, 300 ng/mL rhFlt3, and 50 ng/mL recombinant human IL3 for 16–24 h prior to transduction.8,38 Unstimulated HSPC were kept in the same media in the absence of cytokines during transduction for 16–20 h and then supplemented with the above described human cytokines and 10 mM of the reverse transcriptase inhibitor 3TC (Sigma) to avoid subsequent transduction due to cytokines stimulation. ..



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